CYCLIC STRETCHING-INDUCED EPITHELIAL CELL REORIENTATION IS DRIVEN BY MICROTUBULE-MODULATED TRANSVERSE EXTENSION DURING THE RELAXATION PHASE

Cyclic stretching-induced epithelial cell reorientation is driven by microtubule-modulated transverse extension during the relaxation phase

Abstract Many types of adherent cells are known to reorient upon uniaxial cyclic stretching perpendicularly to the direction of stretching to facilitate such important events as wound healing, angiogenesis, and morphogenesis.While this phenomenon has been documented for decades, the underlying mechanism remains poorly understood.Using an on-stage s

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Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Abstract Human sideroflexin 2 (SFXN2) belongs to the SFXN protein family, which is a mitochondrial outer Dog Food membrane protein involved in mitochondrial iron metabolism.Mitochondria are indispensable for cellular energy production and iron metabolism.However, it remains elusive how SFXN2 modulates mitochondrial homeostasis and cellular iron met

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